GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2629540 | 1 | rs2629540 | chr10:126426148 | METTL10 | chr10:126447406-126480439:- | 0.45 | 6 | 4.61E-9 | Cocaine dependence |
| BLCA | cis | rs2858829 | 1 | rs2637678 | chr6:116787378 | FAM26F | chr6:116782556-116784933:+ | 0.18 | 4.88 | 1.57E-6 | Ulcerative colitis |
| BLCA | cis | rs30187 | 1 | rs26510 | chr5:96125910 | ERAP1 | chr5:96096515-96149837:- | -0.51 | -10.9 | 2.72E-24 | Ankylosing spondylitis |
| BLCA | cis | rs30187 | 1 | rs26510 | chr5:96125910 | ERAP2 | chr5:96211644-96255398:+ | 0.32 | 5.44 | 9.49E-8 | Ankylosing spondylitis |
| BLCA | cis | rs7655841 | 1 | rs2655310 | chr4:130017919 | C4orf33 | chr4:130014829-130033842:+ | -0.34 | -5.57 | 4.86E-8 | Chronic obstructive pulmonary disease (moderate to severe) |
| BLCA | cis | rs1499614 | 1 | rs2659903 | chr7:66180931 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |
| BLCA | cis | rs1499614 | 1 | rs2659911 | chr7:66158420 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |
| BLCA | cis | rs1499614 | 1 | rs2659913 | chr7:66157336 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |
| BLCA | cis | rs9815354 | 1 | rs2683695 | chr3:41914928 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.91 | 9.53E-21 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs2683696 | chr3:41914898 | ULK4 | chr3:41288091-42003660:- | 0.65 | 10.01 | 4.27E-21 | Diastolic blood pressure |
| BLCA | cis | rs2688608 | 1 | rs2688608 | chr10:75658349 | BMS1P4 | chr10:75458909-75490272:- | 0.25 | 4.7 | 3.56E-6 | Inflammatory bowel disease |
| BLCA | cis | rs2688608 | 1 | rs2688608 | chr10:75658349 | SYNPO2L | chr10:75404645-75415832:- | 0.25 | 3.97 | 8.53E-5 | Inflammatory bowel disease |
| BLCA | cis | rs2762051 | 1 | rs2703080 | chr13:50801844 | CAB39L | chr13:49882787-50018221:- | 0.25 | 4.61 | 5.37E-6 | Celiac disease |
| BLCA | cis | rs1499614 | 1 | rs2707828 | chr7:66171377 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |
| BLCA | cis | rs1499614 | 1 | rs2707830 | chr7:66167645 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.69 | 3.85E-6 | Gout |